{"id":2560,"date":"2025-10-07T08:23:12","date_gmt":"2025-10-06T23:23:12","guid":{"rendered":"http:\/\/172.207.84.36\/?page_id=2560"},"modified":"2025-12-18T14:01:50","modified_gmt":"2025-12-18T05:01:50","slug":"repository","status":"publish","type":"page","link":"https:\/\/icrown.jihs.go.jp\/en\/research\/repository\/","title":{"rendered":"Research Utilizing the Repository"},"content":{"rendered":"\n<div class=\"wp-block-vk-blocks-button-outer vk_buttons\"><div class=\"vk_buttons_col vk_buttons_col-justify-left\">\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository_theme_list\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">List of Research Projects Utilizing the Repository<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository-reserach-results\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Research Outcomes from Repository Utilization<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#coviregi-jp\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">COVIREGI-JP<\/span><\/div><\/a><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"repository_theme_list\">List of Research Projects Utilizing the Repository<\/h2>\n\n\n\n<p>Specimens and data provided by contributors are stored in the repository and will be applied to research following reviews from the utilization subcommittee. Details from each study can be found in the list below.<\/p>\n\n\n\n<p>Regarding representative research institutions and principal investigators, cases in which applicants requested not to disclose information (such as companies or academia) have data indicated as \u201cnon-disclosed.\u201d<\/p>\n\n\n\n<p>Please contact us here if, after reviewing the research details in the research project list, you do not wish for your or your family\u2019s specimens or data to be utilized.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2025\/12\/reserach-project-utilizing-repository-251217.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">List of Research Projects Approved by the Utilization Subcommittee [PDF]<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"repository-reserach-results\">Research Outcomes from Repository Utilization<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Publications<\/h3>\n\n\n\n<h5 class=\"wp-block-heading\">\u30082025\u3009<\/h5>\n\n\n\n<h4 class=\"wp-block-heading\">Predictors of in-hospital death among patients with COVID-19 aged &lt; 65 who required invasive mechanical ventilation in Japan<sup><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">New<\/mark><\/sup><\/h4>\n\n\n\n<p>Taniguchi Y, Hosozawa M, Kimura H, Kitajima K, Ohmagari N, Iso H. Predictors of in-hospital death among patients with COVID-19 aged &lt; 65 who required invasive mechanical ventilation in Japan. Respir Med. 2025 Aug 5;247:108289.<br><a href=\"https:\/\/doi.org\/10.1016\/j.rmed.2025.108289\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.rmed.2025.108289<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Discovery of the clinical candidate S-892216: A second-generation of SARS-CoV-2 3CL protease inhibitor for treating COVID-19<sup><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">New<\/mark><\/sup><\/h4>\n\n\n\n<p>Unoh Y, Hirai K, Uehara S, Kawashima S, Nobori H, Sato J, Shibayama H, Hori A, Nakahara K, Kurahashi K, Takamatsu M, Yamamoto S, Zhang Q, Tanimura M, Dodo R, Maruyama Y, Sawa H, Watari R, Miyano T, Kato T, Sato T, Tachibana Y. Discovery of the clinical candidate S-892216: A second-generation of SARS-CoV-2 3CL protease inhibitor for treating COVID-19. J Med Chem. 2025 Jul 5.<br><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00754\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00754<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SARS-CoV-2 BA.2.86 is susceptible to the neutralizing antibody MO11 targeting subdomain 1 despite the E554K mutation near the epitope<sup><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">New<\/mark><\/sup><\/h4>\n\n\n\n<p>Hasegawa N, Nishimura M, Takamiya R, Ishimaru H, Mori Y. SARS-CoV-2 BA.2.86 is susceptible to the neutralizing antibody MO11 targeting subdomain 1 despite the E554K mutation near the epitope. J Virol. 2025 Feb 25;99(2):e0138924.<br><a href=\"https:\/\/doi.org\/10.1128\/jvi.01389-24\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1128\/jvi.01389-24<\/a><\/p>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<h5 class=\"wp-block-heading\">\u30082024\u3009<\/h5>\n\n\n\n<h4 class=\"wp-block-heading\">Improved efficacy of SARS-CoV-2 isolation from COVID-19 clinical specimens using VeroE6 cells overexpressing TMPRSS2 and human ACE2<\/h4>\n\n\n\n<p>Kinoshita H, Yamamoto T, Kuroda Y, Inoue Y, Miyazaki K, Ohmagari N, Tokita D, Nguyen P, Yamada S, Harada S, Kanno T, Takahashi K, Saito M, Shirato K, Takayama I, Watanabe S, Saito T, Ebihara H, Suzuki T, Maeda K, Fukushi S. Improved efficacy of SARS-CoV-2 isolation from COVID-19 clinical specimens using VeroE6 cells overexpressing TMPRSS2 and human ACE2. Scientific Reports. 2024 Oct 22;14(24858).<br><a href=\"https:\/\/doi.org\/10.1038\/s41598-024-75038-4\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1038\/s41598-024-75038-4<\/a><\/p>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-xl--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"coviregi-jp\">COVIREGI-JP<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/icrown-portal.jihs.go.jp\/coviregi\/achievements\/#section03\" target=\"_blank\" rel=\"noreferrer noopener\">Research outcomes for the registry study related to COVID-19 (COVIREGI-JP)<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here is the list of research projects approved by the utilization subcommittee and research outcomes from the iCROWN (Infectious disease Clinical Research netwOrk With National repository) repository utilization, including the COVID-19 registry study (COVIREGI-JP).<\/p>\n","protected":false},"author":8,"featured_media":225,"parent":2559,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/icrown.jihs.go.jp\/?page_id=97","footnotes":""},"class_list":["post-2560","page","type-page","status-publish","has-post-thumbnail","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/comments?post=2560"}],"version-history":[{"count":14,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2560\/revisions"}],"predecessor-version":[{"id":3473,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2560\/revisions\/3473"}],"up":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2559"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/media\/225"}],"wp:attachment":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/media?parent=2560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}