{"id":2589,"date":"2025-10-13T23:12:44","date_gmt":"2025-10-13T14:12:44","guid":{"rendered":"http:\/\/172.207.84.36\/?page_id=2589"},"modified":"2025-12-04T11:16:41","modified_gmt":"2025-12-04T02:16:41","slug":"repository","status":"publish","type":"page","link":"https:\/\/icrown.jihs.go.jp\/en\/stakeholder\/repository\/","title":{"rendered":"Repository Utilization"},"content":{"rendered":"\n<div class=\"wp-block-vk-blocks-button-outer vk_buttons\"><div class=\"vk_buttons_col vk_buttons_col-justify-left\">\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository-overview\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Utilization Overview<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#utilization-basic-policy\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Basic Utilization Policy<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository_03\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Utilization Process<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#specimens-data-provision\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Specimen and Data Submission Process (remaining specimens from existing research, etc.)<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#contract-mta\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Terms, MTA, and Related Documents<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#utilization-status\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Utilization Status<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository-research-results\" class=\"vk_button_link btn has-text-color is-style-outline has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-circle-right vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Research Utilizing the Repository<\/span><\/div><\/a><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"repository-overview\">Utilization Overview<\/h2>\n\n\n\n<p>The iCROWN repository collects, manages, and stores specimens such as blood, swabs, saliva, etc. collected from patients, as well as medical information, for severe acute respiratory infections (including Coronavirus disease 2019), mpox, pediatric hepatitis of unknown etiology, and specimens collected through genomic surveillance at the time of entry into Japan. In addition, collected specimens are subjected to genome analysis, and the results are also stored and managed in the repository.<br>Those wishing to utilize these specimens and data must first pass a screening process.<br>The repository\u2019s provision framework is based on the concept of a trustworthy custodian. While leveraging the benefits of traditional collaborative research agreements and provision (based on MTAs or DTAs), it proposes a new approach to external biobank distribution that differs from both. iCROWN users will retain the results and authorship of their utilization of the repository\u2019s specimens and data. However, they are required to report on the utilization status and cooperate with iCROWN\u2019s investigations.<br>For details, please contact <a href=\"\/en\/inquiry\/contact-us\/\" target=\"_blank\" rel=\"noreferrer noopener\">the inquiry desk (iCROWN Utilization Desk)<\/a>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"\/wp-content\/uploads\/2025\/03\/repository_data_01.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Overview of available specimens and data [PDF]<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2025\/08\/sample-preparation-procedure_Ver1.1.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Specimen preparation procedure [PDF]<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"utilization-basic-policy\">Basic Utilization Policy<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Utilization is available to researchers affiliated with research institutions and companies in Japan.<\/li>\n\n\n\n<li>Research results obtained utilizing specimens and data from the iCROWN repository belong to the user.<\/li>\n\n\n\n<li>When publishing research results, users are required to acknowledge the utilization of data from the iCROWN repository and include a mention in the methods section.<\/li>\n\n\n\n<li>Usage fees are free for both corporate and academic organizations for research that is consistent with the iCROWN repository\u2019s purpose. However, costs necessary for the provision of specimens and data, such as shipping fees, will be the responsibility of the user.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"repository_03\">Utilization Process<\/h2>\n\n\n\n<p>If you wish to utilize the repository, please follow the steps outlined below.<br>Depending on the application status, a waiting period may be required for step 5) Research consultation.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"\/wp-content\/uploads\/2025\/03\/repository_data_03.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Timeline and review flow for specimen and data utilization [PDF]<\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-vk-blocks-accordion vk_accordion\" data-initial-state=\"close\" data-initial-state-mobile=\"\" data-initial-state-tablet=\"\" data-initial-state-desktop=\"\" data-device-specific=\"false\">\n<div class=\"wp-block-vk-blocks-accordion-trigger vk_accordion-trigger\">\n<h4 class=\"wp-block-heading has-text-align-center\">Utilization Process (click to display flowchart)<\/h4>\n<span class=\"vk_accordion-toggle vk_accordion-toggle-close\"><\/span><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-accordion-target vk_accordion-target\">\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">1) Preliminary account registration<\/dt><dd class=\"vk_flow_frame_text_content\">If you already have an account for the iCROWN Repository Portal, you may skip steps 1) to 3) and proceed directly to step 4).<br>If you do not have an account, please click <a href=\"https:\/\/icrown-portal.jihs.go.jp\/AccountRegistration\" target=\"_blank\" rel=\"noreferrer noopener\">[here]<\/a> for preliminary account registration.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">2) Account issuance application<\/dt><dd class=\"vk_flow_frame_text_content\">After completing the preliminary account registration, submit an account issuance application. You may also apply for accounts for your co-researchers at the same time.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">3) Complete e-Learning<\/dt><dd class=\"vk_flow_frame_text_content\">Once you have been issued an account, you will be required to take three e-learning courses (research ethics, pathogen training, and ethics guidelines).<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">4) Browse the showcase<\/dt><dd class=\"vk_flow_frame_text_content\">After completing the e-learning and having your status approved, you can search for specimens and data collected in the iCROWN repository. Please use this information as a reference when considering your application. Log in to <a href=\"https:\/\/icrown-portal.jihs.go.jp\" target=\"_blank\" rel=\"noreferrer noopener\">the Repository Portal<\/a>, and select \u201claunch showcase\u201d from the utilization dropdown menu.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">5) Research consultation<\/dt><dd class=\"vk_flow_frame_text_content\">Contact <a href=\"\/en\/inquiry\/contact-us\/\" target=\"_blank\" rel=\"noreferrer noopener\">the iCROWN Utilization Desk<\/a> via email. We will provide you with an overview of the specimens and data within the iCROWN repository and discuss with you what will be used in your research.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">6) Utilization application<\/dt><dd class=\"vk_flow_frame_text_content\">If the consultation confirms that you can proceed with utilization, we will send you the necessary forms by email. Please fill these out. Once you submit the necessary application documents, we will review them. After confirming that all necessary information has been properly completed, the utilization subcommittee will deliberate on the utilization.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">7) Receive specimens and data<\/dt><dd class=\"vk_flow_frame_text_content\">Upon approval by the utilization subcommittee, a Material Transfer Agreement (MTA) will be concluded.The specimens will then be shipped to you from the Japan Institute for Health Security. Data will be provided to you by the analysis laboratory within the Japan Institute for Health Security.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-off vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">8) Report research outcomes<\/dt><dd class=\"vk_flow_frame_text_content\">Please note that a utilization report must be submitted each fiscal year. Additionally, any research achievements, such as published papers, must also be reported.<\/dd><\/dl><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-xl--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"specimens-data-provision\">Specimen and Data Submission Process (remaining specimens from existing research, etc.)<\/h2>\n\n\n\n<p>It is possible to cooperate with iCROWN by offering to provide specimens or data that were collected through other research or clinical trials separate from iCROWN. We will consider accepting your existing specimens and data into the iCROWN repository on a case-by-case basis. Please contact <a href=\"\/en\/inquiry\/contact-us\/\" target=\"_blank\" rel=\"noreferrer noopener\">the inquiry desk (iCROWN Utilization Desk)<\/a> for inquiries.<\/p>\n\n\n\n<div class=\"wp-block-vk-blocks-accordion vk_accordion\" data-initial-state=\"close\" data-initial-state-mobile=\"\" data-initial-state-tablet=\"\" data-initial-state-desktop=\"\" data-device-specific=\"false\">\n<div class=\"wp-block-vk-blocks-accordion-trigger vk_accordion-trigger\">\n<h4 class=\"wp-block-heading has-text-align-center\">Specimen and Data Submission Process (click to display flowchart)<\/h4>\n<span class=\"vk_accordion-toggle vk_accordion-toggle-close\"><\/span><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-accordion-target vk_accordion-target\">\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">1) Preliminary consultation<\/dt><dd class=\"vk_flow_frame_text_content\">If you wish to provide specimens or data to the iCROWN repository, please contact the iCROWN Utilization Desk via email. We will provide you with further information.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">2) Preliminary account registration<\/dt><dd class=\"vk_flow_frame_text_content\">If you already have an account for the Repository Portal, you may skip steps 2) to 4) and proceed to step 5).<br>If you do not have an account, please click<a href=\"https:\/\/icrown-portal.jihs.go.jp\/AccountRegistration\" target=\"_blank\" rel=\"noreferrer noopener\"> [here] <\/a>for preliminary account registration.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">3) Account issuance application<\/dt><dd class=\"vk_flow_frame_text_content\">After completing the preliminary account registration, submit an account issuance application. You may also apply for accounts for your co-researchers at the same time.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">4) Complete e-Learning<\/dt><dd class=\"vk_flow_frame_text_content\">Those issued an account will be required to take three e-learning courses (research ethics, pathogen training, and ethics guidelines).<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-on vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">5) Download required forms<\/dt><dd class=\"vk_flow_frame_text_content\">Various required forms are available to be downloaded from <a href=\"https:\/\/icrown-portal.jihs.go.jp\" target=\"_blank\" rel=\"noreferrer noopener\">the Repository Portal<\/a>.<\/dd><\/dl><\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-flow vk_flow-arrow-off vk_flow\"><div class=\"vk_flow_frame\"><dl class=\"vk_flow_frame_text\"><dt class=\"vk_flow_frame_text_title\">6) Specimens\/data submission procedure<\/dt><dd class=\"vk_flow_frame_text_content\">Please submit ethics review materials and all other necessary documents to iCROWN. Following approval by the utilization subcommittee and the signing of the contract, specimens and data may be submitted. If requested, we can provide you with the human and pathogen genome sequence data obtained from the specimens you provied.<\/dd><\/dl><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-xl--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"contract-mta\">Terms, MTA, and Related Documents<\/h2>\n\n\n\n<p>Please refer to <a href=\"\/en\/publicity\/public-document\/\" target=\"_blank\" rel=\"noreferrer noopener\">Public Documents &gt; repository related<\/a>.<\/p>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-xl--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"utilization-status\">Utilization Status<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/icrown.jihs.go.jp\/repository-utilization-status_2025-08-27_image\/\" target=\"_blank\" rel=\" noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"720\" src=\"https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2025\/09\/repository-utilization-status_2025-08-27_image.png\" alt=\"\" class=\"wp-image-2502\" srcset=\"https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2025\/09\/repository-utilization-status_2025-08-27_image.png 960w, https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2025\/09\/repository-utilization-status_2025-08-27_image-300x225.png 300w, https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2025\/09\/repository-utilization-status_2025-08-27_image-768x576.png 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/a><\/figure>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-right\"><a href=\"\/en\/research-trial\/repository-utilization-status\/past-repository-utilization-status\/\" class=\"vk_button_link has-text-color vk_button_link-type-text has-vk-color-primary-color btn-md\" role=\"button\" aria-pressed=\"true\" target=\"_blank\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><span class=\"vk_button_link_txt\">Past utilization status can be found here<\/span><i class=\"fa-regular fa-circle-right vk_button_link_after\" aria-hidden=\"true\"><\/i><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-xl--margin-top\"><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"repository-research-results\">Research Utilizing the Repository<\/h2>\n\n\n\n<p>For more information on research utilizing the repository, please <a href=\"\/en\/research\/repository\/\" target=\"_blank\" rel=\"noreferrer noopener\">click here<\/a>.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Learn more about the basic policies and procedures for using the iCROWN (Infectious disease Clinical Research netwOrk With National repository), repository, as well as the process for providing existing research residual specimens to iCROWN.<\/p>\n","protected":false},"author":8,"featured_media":144,"parent":2550,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/icrown.jihs.go.jp\/?page_id=85","footnotes":""},"class_list":["post-2589","page","type-page","status-publish","has-post-thumbnail","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/comments?post=2589"}],"version-history":[{"count":12,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2589\/revisions"}],"predecessor-version":[{"id":3189,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2589\/revisions\/3189"}],"up":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2550"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/media\/144"}],"wp:attachment":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/media?parent=2589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}