{"id":6242,"date":"2026-07-27T10:04:50","date_gmt":"2026-07-27T01:04:50","guid":{"rendered":"https:\/\/icrown.jihs.go.jp\/?page_id=6242"},"modified":"2026-07-27T14:47:02","modified_gmt":"2026-07-27T05:47:02","slug":"repository-research","status":"publish","type":"page","link":"https:\/\/icrown.jihs.go.jp\/en\/research\/repository-research\/","title":{"rendered":"Repository"},"content":{"rendered":"\n<div class=\"wp-block-vk-blocks-button-outer vk_buttons\"><div class=\"vk_buttons_col vk_buttons_col-justify-left\">\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository-overview\" style=\"border-radius:25px\" class=\"vk_button_link btn has-background has-vk-color-custom-2-background-color btn-sm\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-angle-down vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Repository Overview<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#repository-target-infectious-disease\" style=\"border-radius:25px\" class=\"vk_button_link btn has-background has-vk-color-custom-2-background-color btn-sm\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-angle-down vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Targeted Infectious Diseases<\/span><\/div><\/a><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-button vk_button vk_button-color-custom vk_button-align-left\"><a href=\"#specimens-data\" style=\"border-radius:25px\" class=\"vk_button_link btn has-background has-vk-color-custom-2-background-color btn-sm\" role=\"button\" aria-pressed=\"true\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><i class=\"fa-solid fa-angle-down vk_button_link_before\" aria-hidden=\"true\"><\/i><span class=\"vk_button_link_txt\">Specimens and Data Collected in the iCROWN Repository<\/span><\/div><\/a><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<h2 id=\"repository-overview\" class=\"wp-block-heading\">Repository Overview<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">iCROWN collects specimens and clinical information from Research-Implementing Institutions and Semi-Research-Implementing Institutions and stores the prepared specimens, clinical information, and genome analysis information obtained from the specimens. These specimens and data can be utilized for research that elucidates pathogenesis, identifies factors contributing to aggravation and prognosis, improves diagnostic and treatment methods, and contributes to pharmaceutical development. By widely utilizing these specimens and data in various medical research and development activities, the goal is to promote advances in not only infectious diseases but also medicine in general.<\/p>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<h2 id=\"repository-target-infectious-disease\" class=\"wp-block-heading\">Targeted Infectious Diseases<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As of September 2025, the infectious diseases targeted by iCROWN are as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Severe acute respiratory infections (including Coronavirus disease 2019)<\/li>\n\n\n\n<li>Mpox<\/li>\n\n\n\n<li>Pediatric hepatitis of unknown etiology<\/li>\n\n\n\n<li>Priority infectious diseases<sup>*1<\/sup><\/li>\n\n\n\n<li>Specimens collected through genomic surveillance at the time of entry into Japan<sup>*2<\/sup><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">*1 At the 96th meeting of the Infectious Diseases Subcommittee of the Health and Science Council (June 12, 2025), the addition of&nbsp;<a href=\"https:\/\/www.mhlw.go.jp\/content\/10906000\/001503306.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Priority Infectious Diseases<\/a>&nbsp;to the list of target infectious diseases was approved. The iCROWN Administrative Office will begin operations as soon as the specimen<br>collection system is in place.<br>*2 In addition, we accept specimens from other research projects, information obtained through the Ministry of Health, Labour and Welfare's Surveillance Program upon Entry, and residual specimens.<\/p>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<h2 id=\"specimens-data\" class=\"wp-block-heading\">Specimens and Data Collected in the iCROWN Repository<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Available for infectious disease research on emerging and re-emerging infectious diseases.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">\u30fbClinical Information<\/mark><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08Examples\uff09<\/p>\n\n\n\n<div class=\"wp-block-columns has-black-color has-text-color has-link-color wp-elements-b799224838a8e4bd08f100d219de3d42 is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Basic Clinical Information<\/td><td>\u30fbAge\u3000\u30fbSex<br>\u30fbDemographics and comorbidities<br>\u30fbHeight and weight<br>\u30fbDates of first visit, admission, and symptom onset<\/td><\/tr><tr><td>Infectious Disease Information<\/td><td>\u30fbTarget disease test results<br>\u30fbOther pathogen test results<br>\u30fbVaccination history<\/td><\/tr><tr><td>Hospitalization and Treatment Data<\/td><td>\u30fbSymptoms at admission<br>\u30fbClinical outcomes\u3000\u30fbTreatments administered<br>\u30fbHospitalization course (e.g., body temperature, SpO\u2082, heart rate)<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"1200\" src=\"https:\/\/icrown.jihs.go.jp\/wp-content\/uploads\/2026\/07\/2086626.jpg\" alt=\"\" class=\"wp-image-5623\" style=\"aspect-ratio:1.1818644931227713;object-fit:contain;width:265px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-a59283c0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h5 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vk-color-primary-vivid-color\">\u30fbSpecimens<\/mark><\/h5>\n\n\n\n<figure class=\"wp-block-table\"><table style=\"border-width:2px\"><tbody><tr><td>\u30fbPlasma<br>\u30fbPBMCs (Peripheral Blood Mononuclear Cells)<br>\u30fbHuman DNA<br>\u30fbSaliva<br>\u30fbSwab specimens (nasopharyngeal, anterior nasal, throat, and skin lesion swabs)<br>\u30fbStool samples<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h5 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vk-color-primary-vivid-color\">\u30fb<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">Human Genomic Analysis Data<\/mark><\/mark><\/h5>\n\n\n\n<figure class=\"wp-block-table\"><table style=\"border-width:2px\"><tbody><tr><td>\u30fbRaw sequencing data (FASTQ format)*<br>\u30fbMapped sequencing data (CRAM format)*<br>\u30fbGenomic variant data (gVCF, VCF)<br>* Available upon consultation.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<h5 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">\u30fb<strong>Isolated Pathogens and Pathogen Genomic Data<\/strong><\/mark><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The iCROWN (Infectious Disease Clinical Research Network) project collects biological specimens and clinical information and maintains a repository of processed specimens, clinical data, and genomic data generated from these specimens. Here, you can learn about the types of specimens and data available for research, as well as the infectious diseases covered by the repository.<\/p>\n","protected":false},"author":14,"featured_media":137,"parent":2559,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/icrown.jihs.go.jp\/?page_id=4718","sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","_veu_custom_css":"","_exclude_from_list_pages":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","_lightning_design_setting":{"layout":"default","section_base":"default","header_trans":"default"},"header_top_description":"","vk_page_header_image":0,"vk_page_header_image_sp":0,"vk_page_header_subtext":"","footnotes":"","vk-ltc-link":"","vk-ltc-target":"0"},"class_list":["post-6242","page","type-page","status-publish","has-post-thumbnail","hentry","en-US"],"veu_head_title_object":{"title":"","add_site_title":""},"_links":{"self":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/6242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/comments?post=6242"}],"version-history":[{"count":11,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/6242\/revisions"}],"predecessor-version":[{"id":6452,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/6242\/revisions\/6452"}],"up":[{"embeddable":true,"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/pages\/2559"}],"wp:attachment":[{"href":"https:\/\/icrown.jihs.go.jp\/wp-json\/wp\/v2\/media?parent=6242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}