List of Research Projects Utilizing the Repository

Specimens and data provided by contributors are stored in the repository and will be applied to research following reviews from the utilization subcommittee. Details from each study can be found in the list below.

Regarding representative research institutions and principal investigators, cases in which applicants requested not to disclose information (such as companies or academia) have data indicated as “non-disclosed.”

Please contact us here if, after reviewing the research details in the research project list, you do not wish for your or your family’s specimens or data to be utilized.

Research Outcomes from Repository Utilization

Publications

〈2025〉

Predictors of in-hospital death among patients with COVID-19 aged < 65 who required invasive mechanical ventilation in JapanNew

Taniguchi Y, Hosozawa M, Kimura H, Kitajima K, Ohmagari N, Iso H. Predictors of in-hospital death among patients with COVID-19 aged < 65 who required invasive mechanical ventilation in Japan. Respir Med. 2025 Aug 5;247:108289.
https://doi.org/10.1016/j.rmed.2025.108289

Discovery of the clinical candidate S-892216: A second-generation of SARS-CoV-2 3CL protease inhibitor for treating COVID-19New

Unoh Y, Hirai K, Uehara S, Kawashima S, Nobori H, Sato J, Shibayama H, Hori A, Nakahara K, Kurahashi K, Takamatsu M, Yamamoto S, Zhang Q, Tanimura M, Dodo R, Maruyama Y, Sawa H, Watari R, Miyano T, Kato T, Sato T, Tachibana Y. Discovery of the clinical candidate S-892216: A second-generation of SARS-CoV-2 3CL protease inhibitor for treating COVID-19. J Med Chem. 2025 Jul 5.
https://doi.org/10.1021/acs.jmedchem.5c00754

SARS-CoV-2 BA.2.86 is susceptible to the neutralizing antibody MO11 targeting subdomain 1 despite the E554K mutation near the epitopeNew

Hasegawa N, Nishimura M, Takamiya R, Ishimaru H, Mori Y. SARS-CoV-2 BA.2.86 is susceptible to the neutralizing antibody MO11 targeting subdomain 1 despite the E554K mutation near the epitope. J Virol. 2025 Feb 25;99(2):e0138924.
https://doi.org/10.1128/jvi.01389-24

〈2024〉

Improved efficacy of SARS-CoV-2 isolation from COVID-19 clinical specimens using VeroE6 cells overexpressing TMPRSS2 and human ACE2

Kinoshita H, Yamamoto T, Kuroda Y, Inoue Y, Miyazaki K, Ohmagari N, Tokita D, Nguyen P, Yamada S, Harada S, Kanno T, Takahashi K, Saito M, Shirato K, Takayama I, Watanabe S, Saito T, Ebihara H, Suzuki T, Maeda K, Fukushi S. Improved efficacy of SARS-CoV-2 isolation from COVID-19 clinical specimens using VeroE6 cells overexpressing TMPRSS2 and human ACE2. Scientific Reports. 2024 Oct 22;14(24858).
https://doi.org/10.1038/s41598-024-75038-4

COVIREGI-JP