Repository Overview
iCROWN collects specimens and clinical information from Research-Implementing Institutions and Semi-Research-Implementing Institutions and stores the prepared specimens, clinical information, and genome analysis information obtained from the specimens. These specimens and data can be utilized for research that elucidates pathogenesis, identifies factors contributing to aggravation and prognosis, improves diagnostic and treatment methods, and contributes to pharmaceutical development. By widely utilizing these specimens and data in various medical research and development activities, the goal is to promote advances in not only infectious diseases but also medicine in general.
Targeted Infectious Diseases
As of September 2025, the infectious diseases targeted by iCROWN are as follows:
- Severe acute respiratory infections (including Coronavirus disease 2019)
- Mpox
- Pediatric hepatitis of unknown etiology
- Specimens collected through genomic surveillance at the time of entry into Japan
* The addition of Priority Infectious Diseases to the list of targeted infectious diseases is planned. The iCROWN Administrative Office will begin operations as soon as the specimen collection system is in place.
Specimens and Data Collected in the iCROWN Repository
Collected from Research-Implementing Institutions and Semi-Research-Implementing Institutions
- Specimens
*Specimens collected vary depending on the infectious disease.- Blood
- Swabs (nasopharyngeal, skin, etc.)
- Saliva
- Stool
- Sputum
- Clinical information
- Basic information at the time of admission
- Travel information
- History of COVID-19 infection
- Medical history/Complications
- Vital signs at the time of admission
- Pathogen testing
- Medications used during hospitalization
- Treatments performed during hospitalization
- Outcome at the time of discharge
- Laboratory test results during hospitalization
Etc.
Materials provided to users
- Specimens
- Human DNA
- Plasma
- PBMC (peripheral blood mononuclear cells)
- Swabs (nasopharyngeal, skin, etc.)
- Saliva
- Stool
- Sputum
- Isolated pathogens (isolated from the above swabs, saliva, etc.)
- Clinical information
- Collected data (excluding data that can identify individuals)
- Genome analysis information
- Human genome information
- Pathogen genome information
Specimen and Data Collection Status
Coming soon